I'm running 275/45r22 like the stock tires that come on those rims. but thats only cuz I bought them cheap. I was gonna go 305/40r22 just to get more rubber to absorb the road better though. The 275s kind of beat you up. I did notice it takes longer for me to come to a stop so I brake sooner and it did affect my milage, couldnt tell you how much exactly but it does. taking off with a taller tire means you speed up a little slower. I have 3.73s out back so it wasnt that bad. If you have 3.55s you might feel the need to upgrade.